Causes of Peyronie’s Disease
While the exact cause of Peyronie's disease is still unknown, it is believed that injury or trauma to the penis can cause an abnormal healing response, leading to the formation of scar tissue in the tunica albuginea - a layer of tissue surrounding the erectile tissue of the penis. This scar tissue can then cause the penis to curve or bend during erection, resulting in pain or difficulty with sexual activity. Other factors such as genetics, age, and certain medical conditions may also play a role in the development of Peyronie's disease.
There are others who suggest the disease can be hereditary, suggesting a defect in the patient’s genetic make-up. The disease has also been associated with low levels of the male hormone testosterone. The evidence that the disease may have a genetic basis stems from the fact that a positive family history is common. There is also an association with other connective tissue disorders, specifically Dupuytren’s contracture affecting the palms of the hands. Urological Institutes such as the one at Johns Hopkins support the popular theory that Peyronie’s disease is induced by trauma. The trauma may be acute and distinct such as a penile fracture but more often it is chronic and low grade such as repeated attempts at sexual intercourse with weak or incomplete erections.
The disease is a connective tissue disorder of the penis that has been compared to arthritis. Although the disease is quite common – affecting as much as 1 in 11 men despite the lack of public awareness – it is not a disease in the traditional sense of the word. It’s not a disease you can give to others or receive.